The next best thing to do is just to read stories that interest you and click the 'comments' link in the profiles of the authors of comments that seem insightful to you. This can lead you not only to interesting users but interesting threads that you missed the first time around.
https://news.ycombinator.com/user?id=askkk
https://news.ycombinator.com/user?id=yourapostasy
https://news.ycombinator.com/user?id=retskrad
https://news.ycombinator.com/user?id=bogwog
https://news.ycombinator.com/user?id=TheCaptain4815
https://news.ycombinator.com/user?id=sf4lifer
https://news.ycombinator.com/user?id=jerf
https://news.ycombinator.com/user?id=sharemywin
https://news.ycombinator.com/user?id=mnky9800n
https://news.ycombinator.com/user?id=cloudguruab
https://news.ycombinator.com/user?id=informatimago
https://news.ycombinator.com/user?id=kazunori279
https://news.ycombinator.com/user?id=washadjeffmad
https://news.ycombinator.com/user?id=somenameforme
https://news.ycombinator.com/user?id=Decabytes