Some time ago I asked a question at biology stackexchenge [1], and it seems it hadn't received a comprehensive answer.
Additional context is that there are ~10K biochemical reactions happening in ~every cell per second and for a signalling molecule to get to its target it needs to get through a rather dense intercellular milieu.
[1] https://biology.stackexchange.com/questions/88735/how-do-signalling-molecules-find-their-receptors-at-large-distances
[1] below is probably most directly relevent to what your asking, but finer detail is here [2][3]
[1] https://en.wikipedia.org/wiki/Intracellular_transport