How do you hold/use your mouse?
I'm curious, do you move your index finger back and forth between the primary button (left button for most) and the middle button/scroll-wheel, keeping your middle finger stationary on the secondary/right button?
Or do you keep your index finger on the primary, middle finger on the scroll-wheel, and ring finger on the secondary?
Or none of the above?
Right hand index finger for the left button, middle finger on the right button, and I do a lot of right clicks. I've tried using the wheel with the middle finger but it doesn't work well for me. I scroll often, but never use the wheel as a button.
I never use the scroll wheel to 'press' as it hurts my muscles to do that. I do use the scrollwheel heavily though. I own several 'mice' which mitigates wear (I spread the wear across all devices). It's worth experimenting with different mice and find one that suits you. I have basic mice, gaming mice, and both wired and wireless. I prefer wireless as it minimizes drag. The drag is subtle, but it's there, and you will notice it.