What comes after the “pale blue dot” enlightenment?

The answer is that it's all conceptual. There is no real, objective scale to the universe, you're picking a reference point which can feed the monster inside you called depression. It's just as valid to pick a different scale and focus on that. I say that like it's easy, but it's not, it's a struggle, but being aware of it is the first step. It's about where you direct your attention, and how you react to what your attention is focused on. Negativity breeds more negativity, and to break this cycle you must find ways to reverse its polarity. To me that is creative endeavors, which are like dropping a bottled message in the ocean of time hoping that someone in a distant future, in a world I wouldn't recognize, might pick it up and gain something from it. I have that hope because I know I've had that happen to me from people long dead before I was born.

As for reading material, I'd actually recommend Watchmen, the character arc of Dr. Manhattan is pretty much centered around this issue.

Alan Watts said it best.

“The meaning of life is just to be alive. It is so plain and so obvious and so simple. And yet, everybody rushes around in a great panic as if it were necessary to achieve something beyond themselves.”

Happiness is the gap between expectations and reality. This is why Julius Caesar considered himself a bit of a failure - because he compared himself to Alexander the Great. If you frame yourself on the grand scale of the universe as we know it now, that is a heavy weight to bear.

But you can flip this, you may be a mere speck of dust on the wind of cosmic time but how amazing is that!?

The is magic to be enjoyed in the simple things, be it the passing of the clouds or the vista of the night sky. The moon, that is a far out thing to be able to see that. Yes, despite this there is a sense of mourning for the fleeting nature of life but it doesn't matter how much one worries about that - it will not grant you a single second extra in this world. Just enjoy it.

Here is some additional things I will add to this, just some notes I have been working on for a few years. I add to this list as I think of them - about 1 every week or two. I'm not saying that will solve anything but they may help just a little.

http://main.michaelv.fastmail.com.au.user.fm/index.html

Fun question. There was some decent discussion around an article elevating the JWST, disuccsion turning to Pale Blue Dot & what could impact us & how. https://news.ycombinator.com/item?id=35205801

I don't have any answers but this is a solid follow-uo ask.

I don't think mankind really shares in the glory of what we are. And I think a lot of that is because the new world is unknowable, made by closed corporations & defined as intellectual property. An open society that can better apprehend what we are, what we're made of, that can participate & see & study & meddle, I think, would be a different humanity with a better character, a stronger connection to truth & meaning & competency, would find better balances, would better be able to love itself. We are aliens within this world we have made, this world where we are denied knowlesge of all manly things.

  Can you share with me your perspective and/or 
  any reading material on Philosophy/something else?

The latest soon to release I.B.M. machine's operating system brochure says they have A.I. in the works for unskilled operators. I look forward to the day a probe is sent past the point where the selfie of our planet was taken by a probe at double the escape acceleration from our solar system. Continental/French philosophers are depressing, no?

Welcome to existential dread. Try reading Camus.

Nothing wrong with enjoying the simple pleasures. Our lives perhaps don’t have any grand purpose or meaning. That’s ok.

Having children cured me of existential despair.