Haven't had hand/wrist pain in more than three years.
Back when I used mice and keyboards on desks, a big source of pain was small radius and/or sharp corners on the edge of the work surface. So I used work surfaces with large radius edges.
Obviously, the laptop in my lap made that moot.
It's not that I don't like mechanical keyboards and mice.
For me, their pleasures aren't worth the pain.
YMMV.
Good luck.