I'd like to build things with positive impact, and I think collective community brainstorms on HN is a good place to start sometimes.
P.s. Bonus points for ideas that are software related, as I'd love to build software in this space but don't know what's out there or what's needed.
A great business could be one that does the research and are able to publish authoritative reports on their effectiveness. It can be a subscription based report where companies pay a yearly fee.