In addition to the Half Keyboard, which is literally half the size of a regular keyboard, they also make full size keyboards that can be used in this way. I bought a Half Keyboard years ago, for around $100. They now sell for $600, likely because they're making money on ADA-motivated purchases. Employers are much less price-sensitive in those cases.
So the thing about layers is that once you hold the "layer key" (typically in your thumb), all the keys change what they do, and you can choose what it is. So you could have, for example, the first row be QWERT, but once you hold the layer1 key it changes to YUIOP, and then if you hold layer2 it becomes []\arrow-up. And so on. I could probably learn left-handed-only typing like that.