Has anyone tried whole genome sequencing?

Question

Wondering if anyone has tried a service like Nebula.org that claims to offer 100% genome sequencing and reports?Did you find it to be more insightful than partial sequencing like 23&Me? What did you learn?

PragmaticPulp · Accepted Answer

I have a whole genome sequence and a 23 & Me test.
To be honest, neither test produced much usable information. The whole genome produces more results, but I don’t really have anything of great significance in either output.
This seems to be common. The few genome interpretation groups I’ve looked at are full of people trying to extract significant meaning from results that don’t really say much.
Unless you have a major genetic problem, the results of any of these tests aren’t hugely helpful. It’s also too easy to misinterpret the results and think that some of them are more significant than they really are. Most individual genes don’t have a huge effect on overall health, despite what some of the unscrupulous genome analysis sites try to sell you.

Kalanos · Answer

My advice to you is to enroll in the All of US cohort by the NIH. You get blood drawn at a hospital and donate your DNA to research. Eventually they will screen it for known risks.
https://www.nih.gov/news-events/news-releases/nihs-all-us-re...
Make sure to read fine print. Most companies are selling a copy of your DNA to pharma, which is how they keep cost approachable.
Also, most risk scores are for northwest europeans.