Stack Overflow was able to grow huge because it was built on the Microsoft stack. For a long time it ran on a single database server...a big box with lots and lots of disks and RAM. Because it was a business from the beginning, they were willing to pay for sound technology. They could do so because they were adequately capitalized.
Good luck.
If you’re focused just on the thing you’re building use whatever reasonably modern thing you want. I’d probably use flask, MySQL, and avoid a JavaScript framework as long as I could... but that’s just what I’d work fastest in. Do whatever you are most productive in.