If you're tired of SF proper, but the rest of the Bay Area is fine for you and you still want the best tech jobs in large numbers, move to the Peninsula, East Bay, or San Jose.
If you want great tech jobs, slightly lower living costs, and don't mind dreary weather, go to Seattle.
If you want to stay in an urban area with a lot of tech jobs and don't mind high living costs and cold winters, go to NYC.
If you want amazing weather, very few tech jobs, a great nightlife, but don't mind a high living cost, go to LA.
If you want hot weather, decent tech jobs, and lower living costs all around, go to Austin.
There are other options besides these, depending on how much you are willing to trade off having lots of job opportunities, weather, living costs, and other quality of life stuff. Politics and racial diversity may also be pretty different from city to city, so decide how important that is to you.
Indianapolis is not bad, is driving distance to a variety of larger cities and is quite inexpensive. I ended up here by accident but am not motivated to leave, YMMV.
This opens the Mexico City as a fantastic option which is very affordable for someone with a US salary.
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