When building for the web, do you worry about pixel perfect?

Nope. With modern frameworks you get very powerful layout systems but they tend to favor cross-device compability and responsiveness and not the kind of layout control that desktop publishing or Photoshop gives you.

Pixel perfection is very expensive and time consuming across multiple devices. Even resorting to images can be difficult due to device responsiveness. Unless we are talking about highly targeted campaigns that feature single page apps, you won't be bothering with pixel perfect designs for ALL you sites.

Nope, and if someone tries to make you better bill them 20x. Just not what the web is made for, and too large range of devices, browsers and user settings you can't and aren't even intended to be able to control for. (if you are using web tech to target specific environments and not general web users that can be different)

When I wrote the prototype for the Southwest Airlines list page I was able to achieve pixel perfection cross browser except for text. I was working from prepared visual comps and wireframes, so it wasn’t hard.

Pixel perfect is stupid imo, I have a few website /web apps that just use TailwindCSS / TailwindUI classes, they look decent, users love it and they make me money, thats all I care lol

At the moment: Yes! But only for a special case. We’re building a web app that gives a desktop app like experience and wysiwyg exports.

No. We're building a machine learning platform, https://iko.ai, and ML projects aren't held back by the lack of perfect stylesheets.