Is it best to just hire an accountant, use software like turbotax or credit karma, or just do it myself?
I understand that I have to file 4 times a year, so would turbotax/creditkarma handle that as well?
Do I have to file different forms or at different times for income tax vs sales tax?
Any other advice or pointers on good resources for reading would be very much appreciated.
What you are obligated to do is pay estimated taxes due at least quarterly. If you don't do this, you will have to pay a penalty when you "file" at the end of the year.
But, since current interest rates are near zero, the penalty is usually small and the IRS will even figure it for you and left you know the amount you owe.
My advice, forget the accountant, do your own taxes, pay everything due at that time (except the penalty) and let the IRS work the rest out and get back to you as they see fit.
Sales tax is a different animal that varies based on where you live.