Would it be better (both CPU and ram usage) if Slack was opened in the browser instead (preferably Firefox)?
I will say that Slack imposes some seemingly arbitrary restrictions on what you can do with the browser client. Calling is only available in Chrome, which doesn't make a lot of sense to me since both Google Meet and Zoom work fine in Firefox. I find all to be resource intensive during calls with video, but Zoom is by far the worst.
In a pinch I installed the desktop app, and once I had a little bit of spare time I googled around and figured out the issue. Which was that Slack had used 2GB of Cookies/Site Data and Firefox neglected to notify me of that and that appears to be a hard limit and prevent Slack from loading. Clearing the data resolved the issue.
It appears to have worked.