I've never built anything beyond Lego, Meccano and the occasional flatpacked piece of furniture. However, when it comes to "granny pads" the most important thing to take into account is what the specified granny needs, and would like, in her new pad. When my brother added a ground floor extension to the family home specifically for my mother, the two key requirements were for: an en-suite bathroom with a walk-in shower and support rails by the toilet; and to remodel the kitchen with a lower level working surface (because she shrinks as she ages) and accessible (reachable) cupboards/drawers.
tl;dr - consult the granny before you even think of laying a brick for her new pad!