What are other niche verticals where optimization software is in widespread use? (Crude refineries aren't niche, and as far as I know, they are fond of linear programming)
The Apps market for this industry is huge. The Apps department of one of the biggest equipment manufacturers itself, if counted separately, is in top 10 biggest companies in semiconductor equipment companies.
pick a vendor of optimisation software and leaf through case studies or client lists:
Lots of research papers I noticed from Chinese universities about a decade ago on how to best package given dimensions and with constraints like what material cannot be packaged alongside what, into containers of given sizes.