Let the DIYers host their own instances, but offer support and/or on-premise deployments for a fee. It seems to be what Mattermost, Zulip, and others are doing with some success.
Mattermost also includes use of their mobile notification relay servers in their paid offerings, which is compelling, because otherwise you have to build and distribute your own mobile apps.
[0] edited to include reference to important comment
Basically the same as Slack, Trello, etc.
Be careful with per-user billing though, as this puts a lot of big enterprises off.