Make sure you are prospecting well. Do not let time sinks take away from filling your pipe.
Then, send them a "let us not waste one another's time" email or two.
Basically ask whether they want, need contact. No pressure, just want to make sure the activity makes sense for everyone.
This often works. When it does, you get clarity on what makes sense, and often why.
When it doesn't, put those people on low rotation, a ping every few months. Include some news, thing of value and well wishes.
They either unsub, or respond eventually.
By this stage, it should be background activity. Not a time sink.
Sometimes it's just not top priority for the customer or they get distracted. Sometimes, like taxes, it's on their to do list, but they procrastinate on it until it's a bigger problem. Sometimes they've nearly maxed their budget and chose to buy something else.
Some will tell you to stop emailing, some will never respond and some will eventually respond.