I annotate PowerPoint slides directly with Preview.
For other notes, I use FSNotes which is like nvALT and it’s easily searchable and quick to use.
I sometimes edit those MD notes in Typora.
I also like to curate ideas in a Gitbook, which I have public but it’s kinda messy right now. (https://index.kalispera.xyz/)
For some writing projects, I love Scrivener.
I kinda feel like I’m addicted to trying tools though oops.
Had a stint with Microsoft OneNote, but I don't trust it to hold my data reliably.
Ended up with Notes folder with Markdown files. It's very logical (filesystem), easy to backup, version and transfer.
Visual Studio Code is my editor of choice. I'm using custom workspace settings which changes my theme to lighter one, bigger fonts etc whenever I open any note.
It's not perfect. Everytime I want to create note I need to create new file, choose its name and add ".md" extension. It takes 3 seconds, but simple CMD+N would be easier.
Random location, I use my MobiScribe.
At my computer, either the MobiScribe, or Tomboy Notes, sorry of a personal wiki.
At work, possibly needing to be read by others, our group's Knowledge Base, managed by Confluence.